Archive du mois : février 2020

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[Chine] Coronavirus whistleblower doctor is online hero in China

Doctor Li Wenliang is one of the whistleblowers who warned authorities of a potential “SARS-like” outbreak in December 2019, but was reprimanded by Wuhan police instead. The coronavirus has since claimed at least 425 lives and sickened more than 20,000 people globally — including Li and his family. CNN’s David Culver reports.

Fig. 1: Genome characterization of 2019-nCoV. © DR. 0

A Pneumonia Outbreak Associated With a New Coronavirus of Probable Bat Origin

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.

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